Postdoctoral Position in Vision Research. A postdoctoral position is
available to study
molecular aspects of photoreceptor phosphodiesterase metabolism. The type 6
phosphodiesterases (PDE6) are essential enzymes in the phototransduction
process in rod
and cone photoreceptor cells. The PDE6 enzyme in rod cells consists of
and has a complex assembly process that is not fully understood. The
primary mode of
gene regulation is at the level of transcription and the promoters have been
characterized and defined. We are using varied approaches including
characterization in transgenic animals and tissue culture cells, subunit
recombinant adenovirus, and structural studies of purified enzyme to
fundamental processes involving PDE6 in photoreceptor cells. We plan to
expression system for the enzyme, to determine the basis for
expression, and to unravel the basis for the enzymes complex assembly.
The successful candidate will have a Ph.D. degree with experience in
cell biology, biochemistry or related disciplines. Candidates will receive
mouse transgenesis, histologic analysis, protein biochemistry, promoter
many specific aspects of study of the eye. The laboratory is ~2000 sq. ft.
renovated space that is fully equipped for the proposed studies. There are
active grants supporting 7 students, fellows, and research technicians in
The research environment is further enhanced by exceptional core facilities
in the Vision
Science Research Center and an outstanding imaging facility.
For more information, contact:
Steven J. Pittler, Ph.D., Associate Professor
University of Alabama at Birmingham
Vision Science Research Center
924 18th Street South
Birmingham, AL 35294-4390
UAB Web site: "www.uab.edu"
VSRC Web site: "http://main.uab.edu/show.asp?durki=5043"
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