VisionScienceList: fMRI Tutorial Announcement

From: Edgar A. DeYoe (
Date: Fri Aug 25 2000 - 10:40:42 PDT

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                                   AN INTRODUCTORY COURSE

                                     October 12-14, 2000


    This three-day workshop is designed to introduce the basic and clinical
    researcher to the theoretical and practical issues involved in conducting
    functional MRI experiments. Participants will gain an understanding of the
    physiological principles underlying the fMRI signal change, as well as the
    theoretical and practical considerations in research design. The course
    will include firsthand exposure to the scanning environment and data
    collection procedures. Participants will be provided conceptual and
    hands-on experience with data treatment and statistical analysis. At the
    completion of this course, it is expected that participants will be better
    prepared to critique, design, and conduct fMRI studies; appreciate
    limitations and potentials of current fMRI technology and techniques; and
    better understand the expertise required to establish an fMRI research

    Course material will be presented in the form of lectures, problem-based
    learning activities, involvement in an actual fMRI scanning session, and
    instruction in the use of fMRI analysis software. Extensive handouts will
    be provided. Specific topics to be covered by this course include:

      - An introduction to MR physics for the non-physicist
      - Physiological principles underlying the fMRI signal change
      - Various MR pulse sequences used in fMRI experiments
      - Influence of magnet strength and gradient/rf coils in detecting fMRI signals
      - Limits and trade-offs associated with spatial and temporal resolution
      - Detection of potential artifacts in the fMRI signal
      - Issues related to safety and to studying various subject populations
      - Delivering stimuli in the MR scanner environment
      - Recording behavioral and physiological responses in the scanner
      - Preventing and/or correcting head motion
      - Design of task- and drug-activated fMRI experiments
      - Extraction of functional images from fMRI time series data
      - Defining statistical significance in functional images
      - Displaying results in three dimensional space
      - Techniques for comparing results across individuals

    The course is designed to provide the participant with intensive, hands-on
    instruction. As a result, enrollment in the course will be limited to 40


    In 1992, the Medical College of Wisconsin was one of the first medical
    centers (along with Massachusetts General Hospital and the University of
    Minnesota) to demonstrate the BOLD (blood oxygen level dependent) contrast
    mechanism, which forms the basis for most of the fMRI research conducted
    today. Since this initial discovery, MCW has been a leader in fMRI
    research. The multi-disciplinary research effort has been supported by NIMH
    program project and training grants, several NIH individual research grants,
    and private foundation grants. In addition to making neuroscience
    contributions in the areas of vision, motor control, audition/language,
    cognition, epilepsy, and drug abuse, MCW has pioneered the development of
    real-time fMRI, pulse sequences and coil hardware, and a variety of software
    tools for the statistical analysis and presentation of fMRI data. This
    software (Analysis of Functional NeuroImages; AFNI) is currently being used
    by over 300 research centers throughout the world. AFNI will be described in
    detail as part of this course and is available at no cost to research


    This course is designed for basic and clinical researchers interested in
    applying fMRI technology. Knowledge of MR physics, signal processing, or
    the UNIX operating system is not a prerequisite.


    Thursday, October 12

            AM Welcome and Introduction
                            General Introduction to MR Physics
                            MR Physics of Functional MRI Techniques
                            Functional MRI: Principles and Techniques

            PM Functional MRI: Principles and Techniques (cont.)
                            Safety and Subject/Patient Issues
                            Subject Interface Systems

    Friday, October 13

            AM Introduction to fMRI Design Issues
                            Design/Analysis of Drug Effects Using fMRI
                            Psychophysical Approaches to fMRI

            PM Single vs. Blocked Trial Designs
                            Control Tasks in fMRI Experiments
                            Small Group Sessions on fMRI Design
                            fMRI Scanning Session

    Saturday, October 14

            AM Introduction to Statistical Analysis of fMRI Data With
                                AFNI (version 2.22a)

            PM Techniques for Comparing Results Across Individuals


    Stephen Rao, Ph.D. Professor of Neurology (Neuropsychology), Psychiatry,
      (Course Director) Cellular Biology, & Biophysics

    Peter Bandettini, Ph.D. fMRI Methods Unit Chief, NIH
    Michael Beauchamp, Ph.D. Postdoctoral Fellow (Neuroscience), NIH
    Patrick Bellgowan, M.S. Postdoctoral Fellow (Neuroscience), Neurology
    Jeffrey Binder, M.D. Associate Professor of Neurology & Cellular Biology
    Rasmus Birn, M.S. Graduate Student, Biophysics
    Julie Bobholz, Ph.D. Postdoctoral Fellow (Neuropsychology), Neurology
    Robert Cox, Ph.D. Associate Professor of Biophysics
    Edgar DeYoe, Ph.D. Associate Professor of Cellular Biology & Biophysics
    Kathleen Donahue, Ph.D. Assistant Professor of Biophysics
    Sally Durgerian, M.S. Research Assistant, Neurology
    Julie Frost, M.S. Graduate Student (Cognitive Development), Neurology
    Andrew Greene, Ph.D. Professor of Physiology
    Thomas Hammeke, Ph.D. Professor of Neurology (Neuropsychology) and
    Antal Hudetz, Ph.D. Professor of Anesthesiology
    James Hyde, Ph.D. Director of Biophysics Research Institute and
                                   Professor of Biophysics
    Andrew Mayer, M.S. Graduate Student (Neuropsychology), Chicago Medical
    Michael Parsons, Ph.D. Instructor of Neurology
    Edward Possing, M.S. Research Assistant, Neurology
    Thomas Prieto, Ph.D. Assistant Professor of Neurology
    Ziad Saad, M.S. Graduate Student, Cellular Biology
    Elliot Stein, Ph.D. Professor of Psychiatry, Pharmacology, Cellular
                                    Biology, & Biophysics
    Larry Sweet, M.S. Graduate Student (Neuropsychology), Chicago Medical
    Jon Wieser, B.S. Research Assistant, Cellular Biology


    The course will be held in the Health Research Center building of the
    Medical College of Wisconsin (Milwaukee, WI).


    The Medical College of Wisconsin is approved by the American Psychological
    Association to offer 22 Continuing Education (CE) credit hours to
    psychologists for this continuing education activity. Physicians may claim
    Category 2 CME credit for their participation in this activity. The sponsor
    (Medical College of Wisconsin) maintains responsibility for the program.


    Information on this course, an online course registration form, and links
    describing fMRI at the Medical College of Wisconsin are provided at our WEB


    Registration fee is $1,000 for the three-day workshop. This fee includes
    dinner (Thursday evening), lunch, coffee and soft drinks, transportation
    between the hotel and course site, and handouts. Access to the AFNI
    software package is available without charge.

    A reduced enrollment fee of $650 will be provided to a limited number of
    students (graduate/medical students, postdoctoral fellows). A letter from
    the student's mentor is required to verify student status as well as a
    completed student registration form available by contacting Tammy Muth at or 414-454-5661.

    Cost of lodging and additional meals will be assumed by the participant. A
    block of rooms ($74/night) has been reserved at a downtown hotel.
    Additional lodging information will be provided upon registration.

    Interested individuals should complete the online registration form located
    on the course web site ( or contact Tammy
    Muth at or 414-454-5661 (fax: 414-259-9012). Please note that
    enrollment will be limited to the first 40 registrants. Registration fee is
    refundable minus a $50 processing charge until September 29, 2000; after
    this date, fee is nonrefundable.
    Edgar DeYoe. Ph.D.
    Dept. Cellular Biology, Neurobiology and Anatomy
    Medical College of Wisconsin
    8701 Watertown Plank Rd. "In the mountains
    Milwaukee, WI 53226 we forget to
    Ph: 414-456-4920 count the days."
    Fax: 414 -456-6517 (Chinese proverb)

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