VisionScienceList: postdoc position in computational neuroscience

From: Alain Destexhe (
Date: Wed Dec 06 2000 - 09:58:35 PST

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    Postdoc position available - January 1st, 2001
    A postdoc position is available for a computational study of
    neocortical pyramidal neurons in vivo. This project will be conducted
    in collaboration between two laboratories, A. Destexhe (CNRS,
    Gif-sur-Yvette) for the computational part, and D. Pare (Laval
    University, Quebec) for the experimental part. A collaboration with
    Y. Fregnac (CNRS, Gif-sur-Yvette) is also possible. The candidate
    will have access to intracellular data from neocortical neurons in
    vivo, obtained in the aforementioned labs. The project will consist,
    in a first phase, of evaluating the impact of the intense synaptic
    activity in vivo on dendritic integration in neocortical pyramidal
    cells. The morphology of intracellularly-recorded neurons will be
    reconstructed using a Neurolucida system and incorporated in the
    NEURON simulator (, to design biophysical
    models that will be matched precisely to the intracellular
    recordings. Because models and experimental data correspond to the
    same cellular morphologies, we expect that this method will allow us
    to characterize various aspects of synaptic activity in vivo, and
    estimate its consequences on dendritic integration. In a second
    phase, these biophysical models will be simplified, in order to build
    large-scale networks based on the integrative properties estimated
    from in vivo measurements.
    The CNRS facility of Gif-sur-Yvette is a campus entirely devoted to
    research and situated in the vicinity of Paris. The department (UPR
    CNRS 2191, Dir. Y. Fregnac) consists in an integrated and very
    interactive environment comprising in vivo electrophysiology (L.
    Borg-Graham, Y. Fregnac, M. Pananceau, D. Shulz), in vitro
    electrophysiology (T. Bal, K. Grant), comparative anatomy (J-P.
    Denizot), psychophysics (J. Lorenceau) and computational
    neuroscience (A. Destexhe).
    The candidate should have a Doctoral degree, experience in
    neuroscience and computer programming, and ideally, a sufficient
    knowledge of electrophysiology. There is no restriction on
    The salary will be paid by a grant from NIH, which will available on
    January 1st, 2001, for a period of 2 years.
    Candidates should contact Alain Destexhe for more details, or consult
    the site

    Alain Destexhe
    Unite de Neurosciences Integratives et Computationnelles,
    Avenue de la Terrasse,
    91198 Gif-sur-Yvette, France

    Tel: 33-1-69-82-34-35
    Fax: 33-1-69-82-34-27

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