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<p class="MsoNormal"><span style="font-size:11.0pt"><a href="https://www.janelia.org/lab/reiser-lab/positions">https://www.janelia.org/lab/reiser-lab/positions</a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><a href="http://janelia.org/lab/reiser-lab">The Reiser lab</a> at the Janelia Research Campus seeks a creative scientist to join our endeavor to understand circuit transformations in the <i>Drosophila</i> brain. We
use imaging, electrophysiological, behavioral, anatomical, and computational techniques to crack the neural circuits for vision and navigation in <i>Drosophila</i>. This is an exciting time to be working on the fly visual system— one of the best described
complex circuits in neuroscience.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">We are now living through the golden age of <i>Drosophila</i> anatomy, ushered by a much-improved genetic toolkit, advances in light microscopy (LM), and connectomic reconstructions from electron microscopy
(EM) data. Brain regions that were once too complex to be studied at the level of identified neurons, can now have their cells and circuitry catalogued. But these efforts are held back by a lack of computational and analytical tools. Neurons of the fly visual
system lend themselves directly to structure-function questions. How much of a neuron's function could be predicted from its morphology and circuit connectivity? <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">In this position you would lead our efforts to analyze several LM and EM datasets. A number of software tools already exist for anatomical analysis — you would evaluate and use the best of these, and contribute
new code where needed. The specific aim is to establish the central representation of visual information in the fly. Many projects are possible, related to active research topics in the lab:<o:p></o:p></span></p>
<ul style="margin-top:0in" type="disc">
<li class="MsoNormal" style="mso-list:l1 level1 lfo1"><span style="font-size:11.0pt">elucidating the circuit mechanisms giving rise to feature detection in identified neurons. Directional selectivity is an especially active topic. <o:p></o:p></span></li><li class="MsoNormal" style="mso-list:l1 level1 lfo1"><span style="font-size:11.0pt">predicting the flow field selectivity of optic flow sensing neurons from their morphology (and collaborating with others in the lab to measure these responses)<o:p></o:p></span></li><li class="MsoNormal" style="mso-list:l1 level1 lfo1"><span style="font-size:11.0pt">following visual pathways out of the visual system and into the central brain to identify the architecture of behavioral control centers<o:p></o:p></span></li><li class="MsoNormal" style="mso-list:l1 level1 lfo1"><span style="font-size:11.0pt">identifying feedback pathways from the central brain into the visual system that modulate of sensory neurons in response to the behavioral state of the animal <o:p></o:p></span></li><li class="MsoNormal" style="mso-list:l1 level1 lfo1"><span style="font-size:11.0pt">Post-connectome projects, such as localizing critical proteins, especially ion channels, to specific neuronal compartments. Analysis of Expansion Microscopy data. <o:p></o:p></span></li></ul>
<p class="MsoNormal" style="margin-left:.5in"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Several computational extensions of these research areas would be encouraged:<o:p></o:p></span></p>
<ul style="margin-top:0in" type="disc">
<li class="MsoNormal" style="mso-list:l0 level1 lfo2"><span style="font-size:11.0pt">applications of machine learning to these data sets<o:p></o:p></span></li><li class="MsoNormal" style="mso-list:l0 level1 lfo2"><span style="font-size:11.0pt">single neuron biophysical modeling<o:p></o:p></span></li><li class="MsoNormal" style="mso-list:l0 level1 lfo2"><span style="font-size:11.0pt">dynamical systems and network modeling <o:p></o:p></span></li></ul>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">All of these projects would involve direct collaborations with experimentalist in the lab and computational neuroscientists within Janelia, forming a tight loop between anatomical discovery and experimental
methods. A hybrid position is also possible, starting with a focus on the analysis of EM data and then moving on to a functional analysis of these neurons. <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Requirements: Ph.D. in a quantitative field, familiarity with diverse computing environments, comfort with geometric relationships in three-dimensions, and a keen interest in figuring out the brain. Experience
in computational anatomy and/or neuroscience is a big plus. <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Janelia is an exciting research environment (near Washington, D.C.), with abundant opportunities for collaboration. Interested applicants should apply by email; please include your curriculum vitae and research
interests, and arrange for three letters of reference to be sent to reiserm at janelia.hhmi.org.<o:p></o:p></span></p>
<p class="MsoNormal"><i><span style="font-size:11.0pt"><o:p> </o:p></span></i></p>
<p class="MsoNormal"><i><span style="font-size:11.0pt">If you have specific salary requirements, please include them in your e-mail; all information is confidential. HHMI is an equal opportunity employer. </span></i><span style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
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