<div dir="ltr"><p class="MsoNormal" style="margin:0in 0in 0.0001pt;line-height:115%;font-size:11pt;font-family:Calibri,sans-serif">Three
positions are available in the <a href="http://colonneselab.org" style="color:blue">Laboratory
of Systems Neural Development</a> (<a href="http://colonneselab.org">colonneselab.org</a>) at the George
Washington University in Washington, D.C.</p>
<p class="gmail-MsoListParagraphCxSpFirst" style="margin:0in 0in 0.0001pt 0.75in;line-height:115%;font-size:11pt;font-family:Calibri,sans-serif">1.<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman"">
</span>Postdoc
(computational)</p>
<p class="gmail-MsoListParagraphCxSpMiddle" style="margin:0in 0in 0.0001pt 0.75in;line-height:115%;font-size:11pt;font-family:Calibri,sans-serif">2.<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman"">
</span>Postdoc
(electrophysiology or optical imaging <i>in vivo</i>)</p>
<p class="gmail-MsoListParagraphCxSpLast" style="margin:0in 0in 0.0001pt 0.75in;line-height:115%;font-size:11pt;font-family:Calibri,sans-serif">3.<span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-stretch:normal;font-size:7pt;line-height:normal;font-family:"Times New Roman"">
</span>Senior Research Assistant (engineering/signal
processing)</p>
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<p class="MsoNormal" style="margin:0in 0in 0.0001pt;line-height:115%;font-size:11pt;font-family:Calibri,sans-serif"><b>**To apply:
send CV and email brief statement of interest to </b><a href="mailto:colonnese@gwu.edu" style="color:blue"><b>colonnese@gwu.edu</b></a><b> **</b></p>
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<p class="MsoNormal" style="margin:0in 0in 0.0001pt;line-height:115%;font-size:11pt;font-family:Calibri,sans-serif"><b><u>Laboratory Overview:</u></b></p>
<p class="MsoNormal" style="margin:0in 0in 0.0001pt;line-height:115%;font-size:11pt;font-family:Calibri,sans-serif">The
Laboratory of Systems Neural Development is dedicated to understanding the
function of activity in the fetal and infant brain, using the developing visual
system of rodents as a model. Contrary
to long held beliefs, we now know that the fetal brain is not simply an
immature version of the adult brain.
Rather, it is uniquely specialized for the job of wiring up sparsely
connected circuits in a sensory-poor environment. This means that diagnostic and treatment
approaches for neurodevelopmental disorders must follow separate rules when
dealing with the developing brain.
Revealing these differences between the fetal and mature brain is one of
our main goals and is clinically relevant to diagnosing developmental disorders
and monitoring treatment success with EEG and MRI. <b><u></u></b></p>
<p class="gmail-Default" style="line-height:115%;margin:0in 0in 0.0001pt;font-size:12pt;font-family:Arial,sans-serif;color:black"><span style="font-size:11pt;line-height:115%;font-family:Calibri,sans-serif"> </span></p>
<p class="gmail-Default" style="line-height:115%;margin:0in 0in 0.0001pt;font-size:12pt;font-family:Arial,sans-serif;color:black"><span style="font-size:11pt;line-height:115%;font-family:Calibri,sans-serif">We
combine advanced electrophysiological methods with genetic techniques in animal
models of human development <i>in utero</i>
to manipulate activity during early circuit formation. We ask two fundamental questions: (1) How are the
earliest neural circuits specialized to generate and transmit activity, which
is critical for circuit formation? (2) What changes in circuit function must
occur to switch the brain from a fetal mode of function to the adult mode,
which is critical for normal sensory processing and cognition? One of the ultimate
goals of the lab is to create an atlas linking underlying circuit dysfunction
to changes in the EEG of preterm and perinatal infants. Our current focus is on
the role of corticothalamic feedback reticular thalamic nucleus inhibition in
the amplification and synchronization of retinal input and in the developmental
origins of cortical state regulation. </span></p>
<p class="gmail-Default" style="line-height:115%;margin:0in 0in 0.0001pt;font-size:12pt;font-family:Arial,sans-serif;color:black"><span style="font-size:11pt;line-height:115%;font-family:Calibri,sans-serif"> </span></p>
<p class="gmail-Default" style="line-height:115%;margin:0in 0in 0.0001pt;font-size:12pt;font-family:Arial,sans-serif;color:black"><span style="font-size:11pt;line-height:115%;font-family:Calibri,sans-serif">The
PI has a strong focus on training, mentoring and professional development of
candidates.</span></p>
<p class="gmail-Default" style="line-height:115%;margin:0in 0in 0.0001pt;font-size:12pt;font-family:Arial,sans-serif;color:black"><span style="font-size:11pt;line-height:115%;font-family:Calibri,sans-serif"> </span></p>
<p class="gmail-Default" style="line-height:115%;margin:0in 0in 0.0001pt;font-size:12pt;font-family:Arial,sans-serif;color:black"><b><span style="font-size:11pt;line-height:115%;font-family:Calibri,sans-serif">All positions are funded for up to four years.</span></b></p>
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<p class="gmail-Default" style="line-height:115%;margin:0in 0in 0.0001pt;font-size:12pt;font-family:Arial,sans-serif;color:black"><b><u><span style="font-size:11pt;line-height:115%;font-family:Calibri,sans-serif">Job Descriptions:</span></u></b></p>
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<p class="gmail-Default" style="line-height:115%;margin:0in 0in 0.0001pt;font-size:12pt;font-family:Arial,sans-serif;color:black"><u><span style="font-size:11pt;line-height:115%;font-family:Calibri,sans-serif">Computational
Postdoc </span></u></p>
<p class="MsoNormal" style="margin:0in 0in 0.0001pt 0.5in;line-height:115%;font-size:11pt;font-family:Calibri,sans-serif"><span style="color:black">The ideal candidate is a computational neuroscientist with experience
modeling thalamocortical circuits who is interested in developing an
experimentally grounded model of early network dynamics and plasticity as part
of the lab’s established collaboration with Boris Gutkin (Ecole Normale
Superior, Paris) and Jonathan Touboul (Brandeis University, Waltham MA). Depending on interest, there is the
possibility to participate, or be trained in, live animal experiments such as
in vivo electrophysiology and calcium imaging in rodents. Desired:
</span>PhD in Neuroscience or equivalent, experience modeling neural networks, ability to draft manuscript and
grants independently. </p>
<p class="MsoNormal" style="margin:0in 0in 0.0001pt 0.25in;line-height:115%;font-size:11pt;font-family:Calibri,sans-serif"> </p>
<p class="MsoNormal" style="margin:0in 0in 0.0001pt;line-height:115%;font-size:11pt;font-family:Calibri,sans-serif"><u>Electrophysiology/Imaging
Postdoc</u></p>
<p class="MsoNormal" style="margin:0in 0in 0.0001pt 0.5in;line-height:115%;font-size:11pt;font-family:Calibri,sans-serif"><span style="color:black">The ideal candidate is a recent graduate with experience with some form
of electrophysiology or optical imaging interested in working <i>in vivo</i> in neonatal rodents. The lab
uses multi-electrode arrays, patch clamp and calcium imaging, all <i>in vivo</i>. Experience with programming in
Matlab, signal processing, viral expression of genetic modulators of activity,
fiber photometry, or computational modeling of circuits are all pluses. The successful candidate will work on the
interplay of relay thalamus, corticothalamic feedback and the reticular nucleus
of the thalamus during early development, using the visual system as the
primary model. Desired: </span>A PhD in Neuroscience or equivalent, experience with electrophysiological
techniques and analysis, ability to draft manuscript and grants independently. </p>
<p class="MsoNormal" style="margin:0in 0in 0.0001pt 0.25in;line-height:115%;font-size:11pt;font-family:Calibri,sans-serif"> </p>
<p class="MsoNormal" style="margin:0in 0in 0.0001pt;line-height:115%;font-size:11pt;font-family:Calibri,sans-serif"><u>Senior
Research Assistant:</u></p>
<p class="gmail-Default" style="margin:0in 0in 0.0001pt 0.5in;line-height:115%;font-size:12pt;font-family:Arial,sans-serif;color:black"><span style="font-size:11pt;line-height:115%;font-family:Calibri,sans-serif">The ideal candidate is a recent Masters
in Electrical engineering, Biomedical engineering, Computer science etc., with
some course work in digital signal processing and experience programing in
Matlab and Python. Duties include: Improve and maintain imaging and
electrophysiological set-ups, design data analysis pipeline, and implement
signal processing and analysis routines, including, but not limited to,
spike-sorting of high-density neural probes and spectral and state analysis of
depth EEG. Depending on candidate’s
interest, direct participation in animal recordings <i>in vivo</i> are possible. Contributions
to research projects will result in authorship on publications. Exceptional BS students will be considered.
This is an ideal position for a student interested in obtaining research
experience in neuroscience for applications to academia or industry. </span></p>
<p class="gmail-Default" style="line-height:115%;margin:0in 0in 0.0001pt;font-size:12pt;font-family:Arial,sans-serif;color:black"><span style="font-size:11pt;line-height:115%;font-family:Calibri,sans-serif"> </span></p>
<p class="MsoNormal" style="margin:0in 0in 0.0001pt;line-height:115%;font-size:11pt;font-family:Calibri,sans-serif"><b>**To apply:
send CV and email brief statement of interest to </b><a href="mailto:colonnese@gwu.edu" style="color:blue"><b>colonnese@gwu.edu</b></a><b> **</b></p>
<p class="gmail-Default" style="line-height:115%;margin:0in 0in 0.0001pt;font-size:12pt;font-family:Arial,sans-serif;color:black"><b><span style="font-size:11pt;line-height:115%;font-family:Calibri,sans-serif;color:red"> </span></b></p>
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