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<p style="margin-top:0in"><strong><i><span style="font-size:9.0pt;font-family:"Helvetica Neue Light";color:#003056">Scientist I – Modeling Structure-Function Relation in a Reconstructed Cortical Tissue</span></i></strong><o:p></o:p></p>
<p style="margin-top:0in"><span style="font-size:9.0pt;font-family:"Helvetica Neue Light";color:#003056">Our mission at the Allen Institute is to advance our understanding of how the brain works in health and disease. Using a team science approach, we strive
 to discover how the brain implements fundamental computations through the integration of technological innovation, cutting-edge experiments, modeling, and theory.</span><o:p></o:p></p>
<p style="margin-top:0in"><span style="font-size:9.0pt;font-family:"Helvetica Neue Light";color:#003056">Understanding how the structure of biological neuronal networks leads to its observed activity, and how it relates to the implemented computations is one
 of the primary challenges in computational neuroscience. We have large datasets of in-vitro measured cell type properties (https://celltypes.brain-map.org/), statistical knowledge of their connections (<a href="https://portal.brain-map.org/explore/connectivity/synaptic-physiology"><span style="color:#003056">https://portal.brain-map.org/explore/connectivity/synaptic-physiology</span></a>)
 and large-scale recordings of their in-vivo activity (https://observatory.brain-map.org/visualcoding). These are complemented by a fantastic dataset of coupled structure-activity measurement at cell type level in one tissue (<a href="https://microns-explorer.org/"><span style="color:#003056">https://microns-explorer.org</span></a>).</span><o:p></o:p></p>
<p style="margin-top:0in"><span style="font-size:9.0pt;font-family:"Helvetica Neue Light";color:#003056">We are seeking a scientist to join the Modeling and Theory team of Stefan Mihalas help construct <strong><span style="font-family:"Helvetica Neue Light"">data
 driven models of the activity and computations</span></strong> in the mouse cortex. Our team focuses at extracting principles from large data, integrating them in simplified models and using the models to test theories of computation.</span><o:p></o:p></p>
<p style="margin-top:0in"><span style="font-size:9.0pt;font-family:"Helvetica Neue Light";color:#003056">Even with all this data available, directly trying to simulate activity from structure is an under constrained problem. The scientist will work to compare
 existing algorithms to efficiently explore the space of models linking structure to activity and potentially develop new algorithms, if needed. The scientist will explore how additional constrains, including constraints imposed by computations, can be used
 to further narrow down the parameter space. To be able to explore the space of models efficiently, we intend to use on spiking neuron models, with a focus on generalized leaky integrate and fire models. The scientist will work as part of a team to use these
 methods to construct a set of models visually driven in vivo neuronal activity, and subsequently explore the computational properties of these models.</span><o:p></o:p></p>
<p style="margin-top:0in"><strong><span style="font-size:9.0pt;font-family:"Helvetica Neue Light";color:#003056">Essential Functions</span></strong><o:p></o:p></p>
<ul type="disc">
<li class="MsoNormal" style="color:#003056;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1">
<span style="font-size:9.0pt;font-family:"Helvetica Neue Light"">Implement and compare algorithms for automatic parameter optimization in spiking neural network models</span><o:p></o:p></li><li class="MsoNormal" style="color:#003056;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1">
<span style="font-size:9.0pt;font-family:"Helvetica Neue Light"">Help design and construct data driven models for visually driven in vivo neuronal activity</span><o:p></o:p></li><li class="MsoNormal" style="color:#003056;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1">
<span style="font-size:9.0pt;font-family:"Helvetica Neue Light"">Help explore the computational properties of the models</span><o:p></o:p></li><li class="MsoNormal" style="color:#003056;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1">
<span style="font-size:9.0pt;font-family:"Helvetica Neue Light"">Contribute scientific ideas based on the modeling results</span><o:p></o:p></li><li class="MsoNormal" style="color:#003056;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1">
<span style="font-size:9.0pt;font-family:"Helvetica Neue Light"">Develop and maintain computational and associated software tools</span><o:p></o:p></li><li class="MsoNormal" style="color:#003056;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1">
<span style="font-size:9.0pt;font-family:"Helvetica Neue Light"">Publish/present findings in peer-reviewed journals and at scientific conferences</span><o:p></o:p></li><li class="MsoNormal" style="color:#003056;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1">
<span style="font-size:9.0pt;font-family:"Helvetica Neue Light"">Maintain clear and accurate communication with supervisor and other team members</span><o:p></o:p></li></ul>
<p style="margin-top:0in"><strong><span style="font-size:9.0pt;font-family:"Helvetica Neue Light";color:#003056">Required Education and Experience</span></strong><o:p></o:p></p>
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<span style="font-size:9.0pt;font-family:"Helvetica Neue Light"">PhD in computational neuroscience, applied mathematics, computer science or a related field</span><o:p></o:p></li><li class="MsoNormal" style="color:#003056;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l2 level1 lfo2">
<span style="font-size:9.0pt;font-family:"Helvetica Neue Light"">0-2 years of post-doctoral experience.</span><o:p></o:p></li><li class="MsoNormal" style="color:#003056;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l2 level1 lfo2">
<span style="font-size:9.0pt;font-family:"Helvetica Neue Light"">Strong computational/data analysis skills and good programming ability in Python</span><o:p></o:p></li><li class="MsoNormal" style="color:#003056;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l2 level1 lfo2">
<span style="font-size:9.0pt;font-family:"Helvetica Neue Light"">Strong written and verbal communication skills</span><o:p></o:p></li></ul>
<p style="margin-top:0in"><strong><span style="font-size:9.0pt;font-family:"Helvetica Neue Light";color:#003056">Preferred Education and Experience</span></strong><o:p></o:p></p>
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<span style="font-size:9.0pt;font-family:"Helvetica Neue Light"">Strong knowledge of systems neuroscience</span><o:p></o:p></li><li class="MsoNormal" style="color:#003056;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l4 level1 lfo3">
<span style="font-size:9.0pt;font-family:"Helvetica Neue Light"">Experience using PyTorch or TensorFlow</span><o:p></o:p></li><li class="MsoNormal" style="color:#003056;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l4 level1 lfo3">
<span style="font-size:9.0pt;font-family:"Helvetica Neue Light"">Experience simulating spiking neuronal networks using NEST</span><o:p></o:p></li><li class="MsoNormal" style="color:#003056;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l4 level1 lfo3">
<span style="font-size:9.0pt;font-family:"Helvetica Neue Light"">Ability to work as part of a collaborative team</span><o:p></o:p></li><li class="MsoNormal" style="color:#003056;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l4 level1 lfo3">
<span style="font-size:9.0pt;font-family:"Helvetica Neue Light"">Track record of scientific excellence and independent thinking</span><o:p></o:p></li></ul>
<p style="margin-top:0in"><strong><span style="font-size:9.0pt;font-family:"Helvetica Neue Light";color:#003056">Physical Demands</span></strong><o:p></o:p></p>
<ul type="disc">
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<span style="font-size:9.0pt;font-family:"Helvetica Neue Light"">Fine motor movements in fingers/hands to operate computers and other office equipment; lab equipment</span><o:p></o:p></li></ul>
<p style="margin-top:0in"><strong><span style="font-size:9.0pt;font-family:"Helvetica Neue Light";color:#003056">Position Type/Expected Hours of Work</span></strong><o:p></o:p></p>
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<span style="font-size:9.0pt;font-family:"Helvetica Neue Light"">This role is currently able to work remotely due to COVID-19 and our focus on employee safety; this may change, and you may be required to work onsite at our South Lake Union office as safety
 restrictions are lifted in relation to COVID-19.</span><o:p></o:p></li></ul>
<p style="margin-top:0in"><em><span style="font-size:9.0pt;font-family:"Helvetica Neue Light";color:#003056">It is the policy of the Allen Institute to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship
 status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected
 by federal, state or local law. In addition, the Allen Institute will provide reasonable accommodations for qualified individuals with disabilities.</span></em><o:p></o:p></p>
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