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<p class="MsoNormal"><b><span style="color:black">Scientist I - Bio-realistic Modeling of Reconstructed Cortical Tissue</span></b><span style="color:black"><o:p></o:p></span></p>
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<span style="color:black"><a href="https://alleninstitute.hrmdirect.com/employment/job-opening.php?req=1415274" title="https://alleninstitute.hrmdirect.com/employment/job-opening.php?req=1415274"><span style="color:#0563C1">https://alleninstitute.hrmdirect.com/employment/job-opening.php?req=1415274</span></a><o:p></o:p></span></p>
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<span style="color:black"> <o:p></o:p></span></p>
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<span style="color:black">Our mission at the Allen Institute is to advance our understanding of how the brain works in health and disease. Using a team science approach, we strive to discover how the brain implements fundamental computations through the integration
of technological innovation, cutting-edge experiments, modeling, and theory.<o:p></o:p></span></p>
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<span style="color:black"> <o:p></o:p></span></p>
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<span style="color:black">The Allen Institute is seeking exceptional candidates for a BRAIN Initiative-funded position of Scientist in our Seattle-based multidisciplinary organization. The Scientist will join the computational team of Anton Arkhipov and will
focus on data analysis and modeling of structure, activity, and computations in mouse cortical circuits.<o:p></o:p></span></p>
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<span style="color:black"> <o:p></o:p></span></p>
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<span style="color:black">This project will take advantage of unprecedented experimental datasets from the Allen Institute that contain a systematic characterization of synaptic connections between the cell types (<a href="https://portal.brain-map.org/explore/connectivity/synaptic-physiology"><span style="color:#0563C1">https://portal.brain-map.org/explore/connectivity/synaptic-physiology</span></a>)
and a connectome of individual neurons coupled with dense recordings of activity in the mouse visual cortex (<a href="https://microns-explorer.org/"><span style="color:#0563C1">https://microns-explorer.org</span></a>). The Scientist will work collaboratively
with colleagues to integrate these data into new, highly realistic network models of cortical circuits, use the models to explore theoretical predictions, and provide them as a resource to fuel future theoretical, modeling, and experimental work in the community.<o:p></o:p></span></p>
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<span style="color:black"> <o:p></o:p></span></p>
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<span style="color:black">Our computational team collaborates closely with experimentalists to build systematic classifications of structure and function of the mouse visual cortex based on high-throughput recordings in vitro (e.g., Gouwens et al., <i>Nature
Neurosci</i>., 2019; Gouwens et al., <i>Cell</i>, in press, 2020, <a href="https://doi.org/10.1101/2020.02.03.932244"><span style="color:#0563C1">https://doi.org/10.1101/2020.02.03.932244</span></a>) and in vivo (e.g., Siegle et al., <i>Nature, </i>in press<i>, </i>2020, <a href="https://doi.org/10.1101/805010"><span style="color:#0563C1">https://doi.org/10.1101/805010</span></a>).
Using systematically constructed models of neurons from diverse types, we are building and simulating data-driven, highly realistic models of the mouse visual cortex (Arkhipov et al., <i>PLOS Comp. Bio.</i>, 2018; Billeh et al., <i>Neuron</i>, 2020; <a href="https://portal.brain-map.org/explore/models"><span style="color:#0563C1">https://portal.brain-map.org/explore/models</span></a>).
The team also develops and disseminates modeling software (<a href="https://alleninstitute.github.io/bmtk/"><span style="color:#0563C1">https://alleninstitute.github.io/bmtk/</span></a>; <a href="https://github.com/AllenInstitute/sonata"><span style="color:#0563C1">https://github.com/AllenInstitute/sonata</span></a>).<o:p></o:p></span></p>
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<span style="color:black"> <o:p></o:p></span></p>
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<b><span style="color:black">Join us to analyze world-class experimental data and build the next generation of brain models!</span></b><span style="color:black"><o:p></o:p></span></p>
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<span style="color:black"> <o:p></o:p></span></p>
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<b><span style="color:black">Essential Functions</span></b><span style="color:black"><o:p></o:p></span></p>
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<li class="MsoNormal" style="color:black;mso-list:l0 level1 lfo1">Collaborate with in-house experimentalists to analyze data from the synaptic physiology and 2-photon calcium imaging/electron microscopy connectomics datasets.<o:p></o:p></li><li class="MsoNormal" style="color:black;mso-list:l0 level1 lfo1">Use these data to build and simulate models of cortical circuits, in order to study mechanisms connecting circuit structure and function.<o:p></o:p></li><li class="MsoNormal" style="color:black;mso-list:l0 level1 lfo1">Publish/present findings in peer-reviewed journals/scientific conferences.<o:p></o:p></li></ul>
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<span style="color:black"> <o:p></o:p></span></p>
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<b><span style="color:black">Required Education and Experience</span></b><span style="color:black"><o:p></o:p></span></p>
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<li class="MsoNormal" style="color:black;mso-list:l4 level1 lfo2">PhD degree in Neuroscience, Physics, Applied Mathematics, or related fields.<o:p></o:p></li><li class="MsoNormal" style="color:black;mso-list:l4 level1 lfo2">0-2 years of post-doctoral experience.<o:p></o:p></li><li class="MsoNormal" style="color:black;mso-list:l4 level1 lfo2">Strong publication record.<o:p></o:p></li><li class="MsoNormal" style="color:black;mso-list:l4 level1 lfo2">Track record of scientific excellence and independent thinking.<o:p></o:p></li></ul>
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<span style="color:black"> <o:p></o:p></span></p>
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<b><span style="color:black">Preferred Education and Experience </span></b><span style="color:black"><o:p></o:p></span></p>
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<li class="MsoNormal" style="color:black;mso-list:l3 level1 lfo3">Experience in computational neuroscience and/or systems neuroscience is preferred, but other strong applicants will be considered (with background in computational physics, biophysics, and related
disciplines). <o:p></o:p></li><li class="MsoNormal" style="color:black;mso-list:l3 level1 lfo3">Candidates with strong background in experimental systems neuroscience, willing to switch to computational work, are encouraged to apply. <o:p></o:p></li><li class="MsoNormal" style="color:black;mso-list:l3 level1 lfo3">Experience with scientific programming (e.g., in Python) and sharing/collaborative development of software (e.g., GitHub) is a plus. <o:p></o:p></li></ul>
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<span style="color:black"> <o:p></o:p></span></p>
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<b><span style="color:black">Physical Demands</span></b><span style="color:black"><o:p></o:p></span></p>
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<li class="MsoNormal" style="color:black;mso-list:l2 level1 lfo4">Fine motor movements in fingers/hands to operate computers and other office equipment; lab equipment<o:p></o:p></li></ul>
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<span style="color:black"> <o:p></o:p></span></p>
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<b><span style="color:black">Position Type/Expected Hours of Work</span></b><span style="color:black"><o:p></o:p></span></p>
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<li class="MsoNormal" style="color:black;mso-list:l1 level1 lfo5">This role is currently able to work remotely due to COVID-19 and our focus on employee safety; this may change, and you may be required to work onsite at our South Lake Union office as safety
restrictions are lifted in relation to COVID-19.<o:p></o:p></li></ul>
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<span style="color:black"> <o:p></o:p></span></p>
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<i><span style="color:black">It is the policy of the Allen Institute to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex,
sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, the Allen Institute will
provide reasonable accommodations for qualified individuals with disabilities.</span></i><span style="color:black"><o:p></o:p></span></p>
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<span style="color:black"> <o:p></o:p></span></p>
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<span style="color:black">Apply here:<o:p></o:p></span></p>
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<span style="color:black"><a href="https://alleninstitute.hrmdirect.com/employment/job-opening.php?req=1415274"><span style="color:#0563C1">https://alleninstitute.hrmdirect.com/employment/job-opening.php?req=1415274</span></a><o:p></o:p></span></p>
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<span style="color:black"> <o:p></o:p></span></p>
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<span style="color:black"> <o:p></o:p></span></p>
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<span style="color:black"> <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
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