<div dir="ltr"><p class="MsoNormal" style="margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-family:"Calibri Light";background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">Overview
of Laboratory: The Laboratory of Systems Neural Development at The George
Washington University School of Medicine is uncovering the secret life of the
fetal and infant brain. We use advanced electrophysiological methods in animal
models of human development. Combined with genetic techniques to manipulate
activity during early circuit formation in mice, we ask two fundamental
questions: (1) How are visual circuits specialized during early development to
generate and transmit spontaneous retinal activity, which is critical for
circuit formation? (2) What changes in circuit function must occur to switch
the brain from a fetal mode of function to the adult mode, which is critical
for normal sensory processing and cognition? One of the major goals of the lab
is to create an atlas linking underlying circuit dysfunction to changes in the
EEG of preterm and perinatal infants. Our current focus is on the role of the
thalamocortical loop, including the GABAergic reticular nucleus, in the
amplification and synchronization of spontaneous retinal activity and in the
developmental origins of cortical state regulation. </span></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-family:"Calibri Light";background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"> </span></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-family:"Calibri Light";background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">Brief
Description of Position: The lab is recruiting a post-doctoral scientist interested
in the functional development of thalamocortical circuits <i>in vivo</i>. The ideal candidate has some experience with the
recording, imaging and/or analysis of neural activity <i>in vivo</i> or <i>in vitro </i>and
an interest in learning to apply these techniques to the developing brain.
Developmental neuroscientists interested in learning to address early brain
activity are also encouraged to apply.  See
</span><a href="http://www.colonneselab.org/" style="color:rgb(5,99,193)"><span style="font-family:"Calibri Light";background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">colonneselab.org</span></a><span style="font-family:"Calibri Light";background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"> for more information.</span></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-family:"Calibri Light";background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"> </span></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-family:"Calibri Light";background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">Recent
publications from the lab include: </span></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-family:"Calibri Light";background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"> </span></p>

<p class="MsoNormal" style="margin:0in 0in 12pt 0.25in;font-size:12pt;font-family:Calibri"><span style="font-family:"Calibri Light";color:rgb(39,34,62)">Murata Y, Colonnese MT.<span style="border:1pt none windowtext;padding:0in"> (2020)<b> </b></span><span style="border:1pt none windowtext;padding:0in">GABAergic interneurons excite neonatal hippocampus in vivo. <b><i>Science
Advances</i></b> 6(24): eaba1430. </span></span><span style="font-family:"Calibri Light";color:rgb(39,34,62);border:1pt none windowtext;padding:0in">doi: 10.1126/sciadv.aba1430.</span><span style="font-family:"Calibri Light";color:rgb(39,34,62);border:1pt none windowtext;padding:0in"> </span><span style="font-family:"Calibri Light";background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"></span></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt 13.7pt;font-size:12pt;font-family:Calibri"><span style="font-family:"Calibri Light"">Colonnese MT, Phillips AM. (2018)
Thalamocortical function in developing sensory circuits. <b><i>Current Opinion in Neurobiology </i></b>52:
72-79. <i><span style="color:rgb(39,34,62);border:1pt none windowtext;padding:0in"> </span></i></span><a href="https://doi.org/10.1016/j.conb.2018.04.019" target="_blank" style="color:rgb(5,99,193)"><span style="font-family:"Calibri Light";color:windowtext;border:1pt none windowtext;padding:0in;text-decoration-line:none">doi: 10.1016/j.conb.2018.04.019</span></a><span class="gmail-MsoHyperlink" style="color:rgb(5,99,193);text-decoration-line:underline"><span style="font-family:"Calibri Light";color:windowtext;border:1pt none windowtext;padding:0in;text-decoration-line:none"></span></span></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt 13.7pt;font-size:12pt;font-family:Calibri"><span style="font-family:"Calibri Light""> </span></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt 13.7pt;font-size:12pt;font-family:Calibri"><span style="font-family:"Calibri Light"">Murata Y, Colonnese MT. (2016) An excitatory
cortical feedback loop gates retinal wave transmission in thalamus. <b><i>eLife </i></b>5:e18816. <span style="color:rgb(51,51,0);background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">doi:<span class="gmail-apple-converted-space"> </span><span class="gmail-slug-doi"><span style="border:1pt none windowtext;padding:0in">10.7554/eLife.18816.</span></span></span><span class="gmail-slug-doi"><b></b></span></span></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt 13.7pt;font-size:12pt;font-family:Calibri"><span class="gmail-MsoHyperlink" style="color:rgb(5,99,193);text-decoration-line:underline"><span style="font-family:"Calibri Light";color:windowtext;border:1pt none windowtext;padding:0in;text-decoration-line:none"> </span></span></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt 13.7pt;font-size:12pt;font-family:Calibri"><span style="font-family:"Calibri Light"">Berzhanskaya J, Phillips MA, Gorin A, Lai C,
Shen J, Colonnese MT. (2017) Disrupted cortical state regulation in a rat model
of Fragile X syndrome.  <b><i>Cerebral
Cortex </i></b><span style="color:rgb(51,51,0);background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">27(2):1386-1400</span>.
Published online Jan. 2016.</span></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-family:"Calibri Light";background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"> </span></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-family:"Calibri Light";background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">Interested
candidates should email a CV and cover letter describing their interest in the
position to <a href="mailto:colonnese@gwu.edu">colonnese@gwu.edu</a>.</span><span style="font-family:"Calibri Light""></span></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt;font-size:12pt;font-family:Calibri"><span style="font-family:"Calibri Light""> </span></p></div>