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<span class="x_elementToProof x_ContentPasted1 ContentPasted1" style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);">[Dear friends, please find below information about our next Vaegan seminar. Best, Juno]<br>
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<b class="x_ContentPasted0 ContentPasted1">Title:</b> One ellipsoid to control them all — Peptoid anti-infectives that are antibacterial, antiviral, & antifungal </p>
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<b class="x_ContentPasted0 ContentPasted1">Speaker:</b> Dr Josefine E Nielsen (Stanford University)</p>
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<b class="ContentPasted1">Time/Date:</b> 10-11am Friday 02 June 2023 (AEST)<br class="ContentPasted1">
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<b class="ContentPasted1">Location:</b> <span class="x_ContentPasted1 x_ContentPasted2 ContentPasted1">
Zoom. Join from PC, Mac, Linux, iOS or Android: <a href="https://unsw.zoom.us/j/83023210928?pwd=c2tBL2lsdFJMQldaTjNiT09DRVhTQT09" target="_blank" rel="noopener noreferrer" data-auth="NotApplicable" class="x_ContentPasted2 ContentPasted1">
https://unsw.zoom.us/j/83023210928?pwd=c2tBL2lsdFJMQldaTjNiT09DRVhTQT09</a></span><br class="x_ContentPasted2 ContentPasted1">
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<span class="x_ContentPasted1"></span><b class="x_ContentPasted0 ContentPasted1">Abstract:</b>
<span class="x_ContentPasted0 ContentPasted1" lang="EN-US">Infections caused by a variety of microorganisms, including bacteria, viruses and fungi are of increasing global concern, and polymicrobial diseases caused by combinations of microorganisms are recognized
with increasing frequency. Professor Annelise Barron’s lab at Stanford University has developed a library of peptoids (sequence-specific <i class="x_ContentPasted0 ContentPasted1">N</i>-substituted glycine oligomers) that mimic natural antimicrobial peptides,
with broad spectrum activity across different classes of infectious organisms. Peptoids are insensitive to proteases and thus are better drugs than peptides.</span><span class="x_ContentPasted0" style="font-size:13.5pt;font-family:"Times New Roman",serif" lang="EN-US"></span><span class="x_ContentPasted0 ContentPasted1" lang="EN-US">We
discuss how and why differing molecular features between different peptoid candidates affects antimicrobial activity and selectivity, specifically, the self-assembly of the most effective peptoids into discrete micellar structures such as ellipsoidal micelles
comprising ~100 peptoid molecules per micelle, or helical bundles comprising 2-4 peptoid molecules per bundle. </span><span class="x_ContentPasted0 ContentPasted1" lang="EN-GB">We confirm that these peptoids exhibit no apparent cytotoxicity and<i class="x_ContentPasted0 ContentPasted1"> </i>are
well tolerated <i class="x_ContentPasted0 ContentPasted1">in vivo</i>, making them exciting drug candidates as a novel class of broad-spectrum anti-infectives.</span><span style="font-size:13.5pt;font-family:"Times New Roman",serif" class="ContentPasted1"> </span></p>
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<b class="x_ContentPasted0 ContentPasted1">Bio:</b> Josefine Eilsø Nielsen is a postdoctoral research fellow associated both with Stanford University (lab of Prof. Annelise Barron) and Roskilde University (lab of Prof. Håvard Jenssen) studying the self-assembly
of antimicrobial peptides and peptoids, as well as peptide-peptide interactions relevant for the disease development of Alzheimer’s disease, Type 2 Diabetes and Parkinson’s disease. She received her Ph.D. in Biophysical Chemistry from the University of Oslo
in 2020, where she was studying peptide-lipid interactions, using X-ray and neutron scattering.
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<span style="font-size: 11pt; color: rgb(0, 32, 96);" lang="EN-US"><b><span style="font-size: 8pt; font-family: "Arial", sans-serif; color: rgb(77, 77, 77);"></span></b><span style="font-size: 11pt; color: rgb(0, 32, 96);" lang="EN-US"><b><span style="font-size: 9pt; font-family: "Arial", sans-serif; color: rgb(77, 77, 77);">Juno
Kim</span></b><span style="font-size: 9pt; font-family: "Arial", sans-serif; color: rgb(77, 77, 77);"> |
</span><span style="font-size: 8pt; font-family: "Arial", sans-serif; color: rgb(77, 77, 77);"><span style="font-size: 11pt; color: rgb(0, 32, 96);" lang="EN-US"><span style="font-size: 9pt; color: rgb(77, 77, 77);">PhD (Psychology) |</span></span></span><span style="font-size: 9pt; font-family: "Arial", sans-serif; color: rgb(77, 77, 77);">
Associate Professor</span></span><span style="font-size: 6pt; color: rgb(0, 32, 96);" lang="EN-US"></span>
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<i><span style="font-size: 9pt; color: rgb(0, 32, 96);" lang="EN-US">School of Optometry and Vision Science</span></i></div>
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<span style="font-size: 8pt; color: rgb(0, 32, 96);" lang="EN-US">UNSW MEDICINE AND HEALTH<br>
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</span><span style="font-size: 8pt; color: rgb(0, 32, 96);" lang="EN-US">UNSW SYDNEY NSW 2052 AUSTRALIA</span><span style="color: rgb(0, 32, 96);" lang="EN-US"></span><span style="font-size: 10pt; color: rgb(0, 32, 96);" lang="EN-US"><br>
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<span style="font-size: 8pt; color: rgb(0, 32, 96);" lang="EN-US">E: </span><span style="font-size: 10pt; color: rgb(0, 32, 96);" lang="EN-US"><u><span style="font-size:11pt" lang="EN-US"><a href="mailto:juno.kim@unsw.edu.au" title="mailto:juno.kim@unsw.edu.au"><span style="font-size:8pt">juno.kim@unsw.edu.au</span></a></span></u></span><span style="font-size: 8pt; color: rgb(0, 32, 96);" lang="EN-US">
</span><span style="font-size: 10pt; color: rgb(0, 32, 96);" lang="EN-US"><span style="font-size:11pt" lang="EN-US"><span style="font-size: 8pt; font-family: "Arial", sans-serif; color: rgb(77, 77, 77);">|
</span></span></span><span style="font-size: 8pt; color: rgb(0, 32, 96);" lang="EN-US">T: +61 2 9065 1218</span><span style="font-size: 10pt; color: rgb(0, 32, 96);" lang="EN-US"><u><span style="font-size:11pt" lang="EN-US"><a href="mailto:juno.kim@unsw.edu.au" title="mailto:juno.kim@unsw.edu.au"><span style="font-size:10pt"></span></a></span></u></span><span style="font-size: 10pt; color: rgb(0, 32, 96);" lang="EN-US"><br>
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<span style="font-size: 8pt; color: rgb(0, 32, 96);" lang="EN-US">Skype: junokim39</span></div>
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<span style="font-size: 8pt; color: rgb(0, 32, 96);" lang="EN-US">CRICOS Provider Code 00098G</span></div>
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