[visionlist] Post-doctoral position in visual development. Colonnese lab. Washington DC

[matthew colonnese]

Overview of Laboratory: The Laboratory of Systems Neural Development at The
George Washington University School of Medicine is uncovering the secret
life of the fetal and infant brain. We use advanced electrophysiological
methods in animal models of human development. Combined with genetic
techniques to manipulate activity during early circuit formation in mice,
we ask two fundamental questions: (1) How are visual circuits specialized
during early development to generate and transmit spontaneous retinal
activity, which is critical for circuit formation? (2) What changes in
circuit function must occur to switch the brain from a fetal mode of
function to the adult mode, which is critical for normal sensory processing
and cognition? One of the major goals of the lab is to create an atlas
linking underlying circuit dysfunction to changes in the EEG of preterm and
perinatal infants. Our current focus is on the role of the thalamocortical
loop, including the GABAergic reticular nucleus, in the amplification and
synchronization of spontaneous retinal activity and in the developmental
origins of cortical state regulation.



Brief Description of Position: The lab is recruiting a post-doctoral
scientist interested in the functional development of thalamocortical
circuits *in vivo*. The ideal candidate has some experience with the
recording, imaging and/or analysis of neural activity *in vivo* or *in
vitro *and an interest in learning to apply these techniques to the
developing brain. Developmental neuroscientists interested in learning to
address early brain activity are also encouraged to apply.  See
colonneselab.org <http://www.colonneselab.org/> for more information.



Recent publications from the lab include:



Murata Y, Colonnese MT. (2020) GABAergic interneurons excite neonatal
hippocampus in vivo. *Science Advances* 6(24): eaba1430. doi:
10.1126/sciadv.aba1430.

Colonnese MT, Phillips AM. (2018) Thalamocortical function in developing
sensory circuits. *Current Opinion in Neurobiology *52: 72-79.  doi:
10.1016/j.conb.2018.04.019 <https://doi.org/10.1016/j.conb.2018.04.019>



Murata Y, Colonnese MT. (2016) An excitatory cortical feedback loop gates
retinal wave transmission in thalamus. *eLife *5:e18816. doi:
10.7554/eLife.18816.



Berzhanskaya J, Phillips MA, Gorin A, Lai C, Shen J, Colonnese MT. (2017)
Disrupted cortical state regulation in a rat model of Fragile X
syndrome.  *Cerebral
Cortex *27(2):1386-1400. Published online Jan. 2016.



Interested candidates should email a CV and cover letter describing their
interest in the position to colonnese at gwu.edu.
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