[visionlist] Vaegan seminar: Dr Josefine E Nielsen (Stanford University)

[Juno Kim]

[Dear friends, please find below information about our next Vaegan seminar. Best, Juno]


Title: One ellipsoid to control them all — Peptoid anti-infectives that are antibacterial, antiviral, & antifungal

Speaker: Dr Josefine E Nielsen (Stanford University)

Time/Date: 10-11am Friday 02 June 2023 (AEST)

Location: Zoom. Join from PC, Mac, Linux, iOS or Android: https://unsw.zoom.us/j/83023210928?pwd=c2tBL2lsdFJMQldaTjNiT09DRVhTQT09

Abstract: Infections caused by a variety of microorganisms, including bacteria, viruses and fungi are of increasing global concern, and polymicrobial diseases caused by combinations of microorganisms are recognized with increasing frequency. Professor Annelise Barron’s lab at Stanford University has developed a library of peptoids (sequence-specific N-substituted glycine oligomers) that mimic natural antimicrobial peptides, with broad spectrum activity across different classes of infectious organisms. Peptoids are insensitive to proteases and thus are better drugs than peptides.We discuss how and why differing molecular features between different peptoid candidates affects antimicrobial activity and selectivity, specifically, the self-assembly of the most effective peptoids into discrete micellar structures such as ellipsoidal micelles comprising ~100 peptoid molecules per micelle, or helical bundles comprising 2-4 peptoid molecules per bundle. We confirm that these peptoids exhibit no apparent cytotoxicity and are well tolerated in vivo, making them exciting drug candidates as a novel class of broad-spectrum anti-infectives.

Bio: Josefine Eilsø Nielsen is a postdoctoral research fellow associated both with Stanford University (lab of Prof. Annelise Barron) and Roskilde University (lab of Prof. Håvard Jenssen) studying the self-assembly of antimicrobial peptides and peptoids, as well as peptide-peptide interactions relevant for the disease development of Alzheimer’s disease, Type 2 Diabetes and Parkinson’s disease. She received her Ph.D. in Biophysical Chemistry from the University of Oslo in 2020, where she was studying peptide-lipid interactions, using X-ray and neutron scattering.

Juno Kim | PhD (Psychology) | Associate Professor
School of Optometry and Vision Science
UNSW MEDICINE AND HEALTH
UNSW SYDNEY NSW 2052 AUSTRALIA
E: juno.kim at unsw.edu.au<mailto:juno.kim at unsw.edu.au>  | T: +61 2 9065 1218<mailto:juno.kim at unsw.edu.au>
Skype: junokim39
CRICOS Provider Code 00098G


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